How it works?
Anatomy and Physiology of Eyelashes!
Human have 90 to 160 eyelashes in the upper eyelid and 75 to 80 in the lower eyelid, with great variation of length. The lashes typically originate from the anterior lamella of the eyelid where they lie on the tarsal plate. Each human eyelash lives an average of 3 to 6 months. The growth phase (anagen) of the eyelash hair follicle and eyelash lasts for approximately 30 days. At the end of the eyelash growth period, a brief transition stage (catagen) of 15 days follows, with shortening of the hair follicle. Finally, the follicle enters a resting phase (telogen) of about 100 days, leading to the detachment of the eyelash. The length of an eyelash can vary greatly, from 8 to 12 mm in the upper lid and from 6 to 8 mm in the lower lid, and depends on the ethnicity of the individual. Eyelash follicle growth rate is also quite variable, with an average of 0.12 to 0.14 mm daily. All eyelashes are characterized by a tendency to bend from the bulb to the top of the shaft.
Beyond their aesthetic and social functions, eyelashes serve a protective function by defending the eye against debris and triggering the blink reflex.
Bimatoprost ophthalmic solution 0.03% is the only FDA-approved product to safely and effectively enhance the growth of a patient’s own eyelashes. Bimatoprost is a synthetic prostamide, or prostaglandin ethanolamide. It is structurally similar to the other prostaglandin F2α (PGF2α) analogs, including latanoprost, travoprost and unoprostone, but has an ethyl amide instead of an isopropyl ester at the C-1 carbon of the alpha chain. Bimatoprost has been proposed to be similar to a class of naturally occurring fatty acid amides otherwise known as “prostamides” (prostaglandin ethanolamides).
Prostaglandins are probably involved in a specific and complex network in hair growth and differentiation control. Most of the hair cell types are endowed with prostaglandin metabolism machinery and are able to produce PGE2 and/or PGF2α; and all prostaglandin receptors are present in hair follicle. Prostaglandin analogs may also prolong the anagen phase of eyelashes, leading to an increase of eyelash length. The safety and efficacy of once-daily bimatoprost 0.03% solution in increasing overall eyelash prominence following dermal administration to the upper-eyelid margins. Bimatoprost most likely works by interacting with the prostaglandin receptors in the hair follicle and stimulating the resting follicles (telogen phase) to growing follicles (anagen phase). Although bimatoprost is effective in promoting increased growth of healthy eyelashes and adnexal hairs.
- Hyaluronic acid abbreviated HA; conjugate base hyaluronate, also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. HA may be involved in various cellular interactions (cell differentiation, proliferation, development, and recognition) and physiological functions (lubrication, hydration balance, matrix structure, and steric interactions). The role of Hyaluronic Acid towords eyelashes is to strengthen and reinforce them overtime. It ensures lashes stay beautiful and helps to repair damage caused by heavy mascara use, extensions and false lashes. It provides a holistically successful formula that cares for the eyes and protects them from redness and dehydration of the skin. Due to its moisture locking trait, Hyaluronic acid also plays a part in controlling the hair loss. HA not only provides a boost to hair growth, but it also increases the diameter of individual hairs.